The proposed relationship of Sarah Rippin as the mother of Isaac Muxlow and Eliza Muxlow is supported by DNA evidence indicating shared ancestry within the family lines.

Specifically, DNA evidence confirms a 2nd cousin, once removed relationship between JS (a descendant of the Isaac Muxlow ancestral line) and JA (a descendant of the Eliza Muxlow ancestral line) with a shared segment of 182.23 cM across 7 HIR segments.

This match is consistent with their placement within these shared ancestral branches.