The paternal relationship between Isaac Henry Pennington and his son Venice Edrin Pennington is confirmed by the direct inheritance path of autosomal DNA down to their DNA tested descendant JPS.

The segmental (via DNA segment triangulation) and total DNA shared between JPS and other confirmed descendants of Whitson Pennington/Mary Chapman is consistent with the expected ranges for their respective relationships. Since JPS descends from Whitson Pennington/Mary Chapman through Isaac Henry Pennington and his son Venice Edrin Pennington, the presence of significant shared DNA between JPS and other known descendants of Whitson Pennington/Mary Chapman validates the generational links along this paternal line.

This supports the conclusion that DNA was passed from MRCA couple Whitson Pennington/Mary Chapman through Isaac Henry Pennington to Venice Edrin Pennington, and ultimately to JPS, confirming this direct ancestral connection through multiple generations.